Factors affecting survival in esophageal squamous cell carcinoma: Single-center experience

Abstract

OBJECTIVE: Squamous cell esophageal cancer (ESCC) is a highly fatal malignancy. This study aims to investigate the factorsaffecting survival in patients with metastatic and non-metastatic ESCC.METHODS: Between 2008 and 2016, 107 patients with ESCC who were followed up in an oncology clinic were included inthe analysis. Patients were grouped based on the stage of disease as clinical-stage II to IV.RESULTS: Of the 107 patients, 55 (55.1%) of them were male and 52 (48.6%) of them were female. The mean age was60.8 years. Based on the clinical-stage, 28 (26.2%) patients had stage II disease, 33 (30.8%) had stage III disease, and 46(43.0%) had stage IV disease. Twenty-nine (27.1%) patients with the non-metastatic disease underwent surgery followingneoadjuvant chemoradiotherapy (CRT), while 29 (27.1%) patients received definitive CRT. Twenty-six (56.5%) patients withmetastatic disease received chemotherapy (CT). While median overall survival (mOS) could not be reached in patients whounderwent surgery following neoadjuvant CRT, mOS for patients receiving definitive CRT versus patients treated with surgeryalone–was 22.0 months and 24.0 months, respectively (p=0.008). In the metastatic stage, mOS was 8.0 months for thepatients treated with a first-line CT and 3.0 months for patients receiving best supportive care (p