Drug and Herb induced liver injury: a short review

Abstract

Chemical induced liver injury is a pathological condition caused by diver’s medications and other xenobiotics, leading todeficiencies in liver functions with the elimination of other diagnosis. Liver injury is prevalent in the world and can result inserious clinical outcome and has possibly fatal outcome. Chemical induced liver injury has an estimated annual incidence10-15 per 10,000-100,000 patients received several prescription medications. The kind of liver injury are almost 10% caseswith acute hepatitis, and is the most common cause of acute liver failure in the United States. Also, liver injury appeared afterapproval for marketing has restricted the use of many drugs (e.g., isoniazid, labetalol, and felbamate). Therefore, especiallydrug-induced liver injury is currently the major reason for discontinuation of a new compound in development or for withdrawalof a successfully launched drug from the market. In this review, we researched that mechanisms of liver injury withdrugs and herbal preparations, and potential risks have been reported.