Effects of Duraseal® and Fibrin Glue on healing of normal and ischemic colon anastomosis

Abstract

Background and Aims: Anastomotic leaks represent a major complication of colorectal surgery. This study, involving a ratmodel of normal and ischemic colon anastomosis, aims to compare the effects of Duraseal® with those of Fibrin Glue (FG).Methods: Fifty adult male Wistar Albino rats were divided into six groups; normal colon anastomosis, ischemic colon anastomosis, FG on normal colon anastomosis, Duraseal® on normal colon anastomosis, FG on ischemic colon anastomosis, Duraseal® on ischemic colon anastomosis. After scarification, bursting pressure were measured and samples were collected forhistopathological examination and hydroxyproline assays.Results: While the mean bursting pressure was statistically higher in groups treated with Duraseal® when compared to controls (p0.05). The mean hydroxyproline levelwas significantly lower in the Duraseal® groups than in the FG groups (p