Some Serum Oxidative Parameters in Normoglycemic Rats: Vascular Endothelial Growth Factor (VEGF) Application

Abstract

VEGF has the positive effect on wound healing. In this study, the effect of VEGF application on some serum parameters during wound healing process were investigated. 36female normoglycemic Wistar rats were used (200–250 g). Dorsolateral incisional wounds(length: 4 cm) were made on the two sides of the medulla spinalis in rats. They were divided into 3 groups: untreated group (n=12), chitosan group (n=12) and chitosan+VEGFgroup (n=12). The rats were sacrificed on the 3rd and 7th days of post wounding. NOx,TBARs and RSH levels were determined spectrophotometrically in serum. Results werecompared by one-way ANOVA (p