Effects of Midazolam, Propofol and Thiopental on Gastric Ulcer in Rats Midazolam

Abstract

Introduction: The peresent study was conducted to research whether the intravenous (iv) anesthetics of propofol, midazo- lam and thiopental have a protective effect against gastric injury induced in rats with indomethacin. Methods: Rats were randomly divided into 6 groups (n=7). Rats in Group 1 (n=7) had 8 ml/kg saline administered via gavage. Rats in Group 2 (n=7) were administered 25 mg/kg indomethacin via gavage. Rats in Group 3 (n=7) were given 20 mg/kg famotidine intraperitoneal. Rats in Group 4 (n=7) were given 40 mg/kg propofol intraperitoneal. Rats in Group 5 (n=7) were administered 40 mg/kg thiopental intraperitoneal. Rats in Group 6 (n=7) were administered 10 mg/kg midazolam intraperi- toneal and then 5 minutes later 25 mg/kg indomethacin via gavage in all groups except Group 1. All groups were sacrificed 6 hours after administration of oral indomethacin and gastrectromy was performed. All samples were photographed. Macro- scopic photographs were uploaded to a computer. A pathologist used the“Olympus Stream Start”image analysis method to measure the size of the ulcer areas on photographs of each stomach excision sample in “pixels”. The total number of ulcers and total ulcer area were calculated for each rat. Other pieces of gastric tissue were assessed with histopathological study. Results: Clear ulceration was observed in the gastric mucosa of the indomethacin group. The iv anesthetic medications of propofol, midazolam and thiopental used in the study did not have any antiulcer efficacy. Discussion and Conclusion: It was determined that propofol, midazolam and thiopental had no protective effect against gastric injury induced in rats with indomethacin.