Dergiler / FABAD Journal of Pharmaceutical Sciences / 2001 / Cilt: 26 - Sayı: 3
Synthesis and antimicrobial activities of some substituted thiosemicarbazides, 1,2,4-Triazole-5-thiones and their 5-methyl derivatives
- Sayfa
- 113–117
- DOI
- —
Özet
Özet : 1-Naftolden hareketle yeni l-[(l-naftil)oksiasetil]-4-sübstitüe-tiyosemikarbazit, 3-[(l-naftil )oksimetilJ-4-sübsti-tüe-1,2,4-triazol-5-tiyon ve 3-[(l-naftil)oksimetil]-4-sübsti-tiie-5-metilmerkapto-l,2,4-triazol türevleri sentez edilmiştir. Bileşiklerin kimyasal yapıları IR, lH-NMR ve eleman analizleri ile kanıtlanmıştır. Sentezi yapılan bileşiklerin antifungal ve antibakteriyel aktiviteleri Staphylococcus aureus, Enterococcus faecalis, Escherichia coli ve Pseudomonas aeruginosa, Candida albicans, C. krusei ve C. parapsilosis 'e karşı mikrodilüsyon yöntemi kullanılarak incelenmiştir.
Abstract
Summary : A series of new 1- [(l-naphthyl)oxyacetyl]-4-substituted-thiosemicarbazides, 3-[( 1 -naphthyljoxymethyl]-4-substituted-l,2,4-triazole - 5 - thiones and 3-[(l-naphthyl) oxymethyl]-4-substituted-5-methylmercapto-l,2,4-triazoles have been synthesized from 1-naphthol. The chemical structures of the compounds were proved by IR,1H-NMR and elementary analysis. Antimicrobial activities of the synthesized compounds were investigated against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa, Candida albicans, C. krusei and C. par-apsilosis by the microdilution method.