Evaluation of antimicrobial activities of some dioxolane derivatives

Özet

Bu çalışmada sentezleri daha önceden yapılan, azol ve kondanse azol halkaları içeren dioksolan türevi on tane bileşiğin ikisi Gram-positif (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212) ve ikisi Gram-negatif (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) olmak üzere toplam 4 bakteri ve 3 maya benzeri fungusa (Candida albicans ATCC 90028, Candida krusei ATCC 6258 ve Candida parapsilosis ATCC 22019) karsı antibakteriyel ve antifungal etkileri incelenmiştir. Bileşiklerin aktiviteleri mikrodilüsyon yöntemiyle tayin edilmiş ve Cefiazidime ve Fluconazole standart olarak kullanılmıştır. Bileşik 9 ve 10, S. aureus'a karşı (4 $mu$/ml) etkili bulunurken bileşik 1 ve 4, C. krusei'ye karşı (32 $mu$/ml), bileşik l (8 $mu$/mi) ve bileşik 6 (4 $mu$g/ml) ise C. albicans'a karsı aktif bulunmuştur.

Abstract

In this study antibacterial and antifungal activ-ities of the synthesized ten dioxolane derivatives which contain azole and condensed azole ring in their structure were determined against 4 bacteria, 2 of them are Gram-positive (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212) and 2 of them are Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) and 3 yeast-like fungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258 and Candida parapsilosis ATCC 22019). The activities of the compounds were determined by the broth microdilution method and Cefiazidime and Fluconazole were used as standards. Compound 9 and 10 showed activity (4$mu$/ml) against S. aureus, compound 1 and 4 showed activity (32 $mu$/ml) against C. krusei, compound 1 (8 $mu$/ml) and compound 6 (4 $mu$/ml) showed activity against C. albicans.