Effects of IVIG and Pulse Steroid Therapy in a Case of Allopurinol Induced DRESS Syndrome

Abstract

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a drug reaction that causes peripheral eosinophilia and primarilyrenal and hepatic insufficiency and dysfunction of other visceral organs with skin rash as noticeable symptom. Early diagnosisand discontinuation of the culprit drug along with rapid treatment are required to reduce mortality rate. Herein, a case ofallopurinol-induced DRESS syndrome is presented in which the patient was resistant to medium dose systemic steroid therapyand was treated with pulse steroid and IVIG treatment successfully. Pulse steroid therapy may be an alternative treatment optionin refractory DRESS syndrome.