The Role of Nitric Oxide Related Therapeutics in the Treatment of Cardiovascular Pathologies

Abstract

The heart is a bio pump responsible for the provision of oxygen and nutrients to all body cells. It plays a vital role in the survivalof the organism. The essential function of the heart is performed through the close interaction of the cardiac myocytes with theendocardial and capillary endothelial cells. The endothelium releases nitric oxide (NO) and modulates several physiological andpathological processes. The cardiac myocyte is also capable of NO production. Although the effect of NO on cardiac responses hasbeen examined, data regarding the effect of NO on the heart remain controversial. The discrepancies in studies can be explainedby several factors, such as different animal species, preparation, redox status, and NO concentration. However, an increasing interest in the role of NO has generated significant progress in the investigation of NO-based therapies. In this review, first, the generalproperties of NO are described as well as the physiological functions and pathological role in the heart. Then, an evaluation ismade of several important NO-related treatment options, such as NO donors, NO synthase inhibitors, phosphodiesterase inhibitors, and soluble guanylate cyclase stimulators/activators. A summary is also given of NO-based drug candidates planned for usein clinical trials in the near future.