Surgical Treatment Results in Unilateral Wilms Tumor: Experience from a High-Volume Pediatric Oncology Center in Turkey

Abstract

Objective: The aim of the present study was to evaluate the clinical characteristics, factors affecting treatment approach, and longterm outcome of patients with Wilms tumor. Methods: We identified the demographic features, mode of presentation, applied treatments, and long-term outcomes of 88 patients treated between 1990 and 2011 at Hacettepe University İhsan Doğramacı Children’s Hospital according to the Turkish Pediatric Oncology Group protocol. Data were analyzed using SPSS program, and chi-square test was used for statistical analysis. Results: The study included 88 patients (50 females and 38 males) with a mean age at presentation of 3±2.48 years. Patients were classified as stage 1 (n=35, 39.8%), stage 2 (n=16, 18.2%), stage 3 (n=17, 19.3%), and stage 4 (n=20, 22.7%). Pathological examination of tumors revealed favorable histology in 76 (86.4%) patients and unfavorable histology in 10 (11.4%) patients. Forty-nine (55.6%) patients received preoperative chemotherapy, and patient’s age at diagnosis and physical examination findings influenced the decision of the administration of preoperative chemotherapy (p