Topical Povidone-Iodine as an Adjunctive Treatment for Recalcitrant Chronic Rhinosinusitis

Abstract

Objective: Recalcitrant chronic rhinosinusitis (CRS) is a persistent inflammation of the sino-nasal mucosa despiteappropriate medical therapy and sinus surgery. The aim of the present study was to demonstrate the effect of topical povidone-iodine (PVP-I) sinus rinses on modified Lund–Kennedy (MLK) endoscopic scores.Material and Methods: Retrospective chart review of patients with recalcitrant CRS (n=69) previously prescribed0.08% adjunctive PVP-I sino-nasal rinses to evaluate changes in MLK scores and in the 22-item Sino-Nasal OutcomeTest (SNOT-22) and a prospective cohort study lasting 7 weeks (n=17) were used to investigate safety outcomes.Results: Mean total MLK decreased by 2.01 points (p