Hemophagocytic lymphohistiocytosis after certolizumab treatment in a patient with rheumatoid arthritis

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome that may betriggered by hereditary factors, autoimmune and immunologic disorders, infectious diseases, malig-nancies and medications. Suspicion of the disease and early treatment is of paramount importance.Since the presentation of HLH with only skin involvement is rare, early diagnosis may be difficult. Apathologically confirmed HLH case that presented with maculopapular skin lesions after certolizum-ab treatment is being reported in this presentation.