Positive anti-MOG antibodies in a patient with Sjögren's syndrome and transverse myelitis

Abstract

Twenty percent of patients with Sjögren’s syndrome experience associated neurological disease.Transverse myelitis (TM) frequently forms part of a neuromyelitis optica spectrum disorder associatedwith the presence of anti-aquaporin 4 (AQP4) antibodies. We report the first described case of a patient who developed TM and the presence of a newly recognized antibody, anti-myelin oligodendrocyte protein (MOG), who went on to develop Sjögren’s syndrome. AQP4 and MOG antibodies shouldbe tested to guide prognostically the chances of further relapse as well as the type and duration ofimmunotherapy in patients with coexisting Sjögren's syndrome and TM.