Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors

Abstract

Objective: Th clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. Th aim ofstudy is to fid the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factorsin breast cancer patients.Materials and Methods: Between 2010 and 2017, patients with invasive ductal carcinoma who received radiotherapy after surgery were included in study. A single pathologist re-defied of all cases retrospectively. Ki-67 were established three categories based on Ki-67 levels: low (25%).Results: A total of 258 patients were included. 46 of 258 (18%) patients were in low, 82 of 258 (32%) patients were in intermediate and 130 of258 (50%) patients were in high Ki-67 group. Thre were no correlations between menopausal status, age, and Ki-67 level. Low-pT stages tended tohave low Ki-67 expression (p=0.07). Low-pN stages correlated with low Ki-67 values (p=0.007). Patients with ECE (+) were prone to have higherKi-67 values (p=0.02). Th signifiant correlation was seen between Ki-67 and tumour grading (p=