Relationship Between Proliferative Breast Lesions and Breast Cancer Risk Factors

Abstract

Objective: The prognosis of breast cancer (BC) is determined directly based on the stage of disease at the time of diagnosis. Proliferative breast lesions(PBLs) are an important risk factor for BC development. The risk of developing BC varies according to the presence of extent of proliferation in the breastlesions. We aimed to investigate the effect of BC risk factors on the PBLs in this study.Materials and Methods: Patients who visited the surgical clinic of the university during the past 6 years who presented with PBLs with or without atypiaby fine/core needle aspiration biopsy were included in this study. The relationship between PBLs and BC risk factors such as the age, mass size, Body Massindex (BMI), smoking, sports activity, BC family history, the use of hormone replacement therapy, number of pregnancies, and the duration of breastfeedingwere compared.Results: A total of 74 (96.1%) of all patients were women and three were men. The median age of the patients was 38 (range: 19–74) years; the cut-offvalue of age was 35.5 years. The mean age of patients with PBL-with atypia (PBL-WA) was higher (p=0.005) in the malignant group based on the finalpathology and radiological imaging features (for both, p