Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects

Abstract

Objective: Ghrelin is a hormone with peptide structure. It has fatty tissue and increases appetite. Obesity is a multifactorialchronic disease characterized by an increase in fat tissue. Fat tissue, like the endocrine organ, triggers oxidative stress and canlead to the development of obesity-related pathologies. The purpose of this study is to examine the relationship between theghrelin in blood, and oxidative stress and lipid parameters.Materials and Methods: The study was conducted with 61 obese and 24 healthy individuals. Ghreline levels were measuredusing the ELISA method, while total antioxidant status (TAS) and oxidant status (TOS), triglyceride (TG), total cholesterol (TC),HDL-cholesterol (HDL-C) and LDL cholesterol (LDL-C) levels were measured using the photometric method.Results: A negative correlation was found between body mass index (BMI) and ghrelin levels in the obese group (p0.05). TAS was observed to be lower in obesecompared to control group, while The Oxidative Stress Index (OSI) was found to be significantly higher than the obese group(p0.05).Conclusion: Increasing obesity level (BMI) and decreasing ghrelin level were found to be correlated. New studies are neededin order to discover the changes in ghrelin level connected to oxidative stress.