Extended Duration of Adjuvant Temozolomide inGlioblastoma Multiforme – A Review of Trials

Abstract

Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy then adjuvantTMZ is the current standard treatment for glioblastoma multiforme (GBM). There is a lot of controversy regarding theduration of adjuvant TMZ. The standard guidelines recommend 6 months of adjuvant treatment, however in clinicalpractice in a lot of centers around the world, TMZ therapy is continued beyond 6 months duration. In this reviewarticle we will discuss both favorable and unfavorable trials regarding extended TMZ therapy and try to analyze inwhom extended TMZ therapy is beneficial and whether or not it should be offered.