Dialister in Microbiome of Cancer Patients: A SystematicReview and Meta-Analysis

Abstract

Objectives: Dialister is the genus classified within Veillonellaceae family in Firmicutes phylum. Dialister genus has beendetected in patients with oral infections and healthy people in their oral cavity, as well as in clinical samples in differentparts of the body. Cancers are complex and multifactorial diseases and considered a global problem. End products ofDialister such as acetate, lactate and propionate seem to be important in the mechanism of carcinogenesis. Althoughit is reported that the composition of Dialister has changed in articles investigating the microbiome relationship withcancer patients, it is seen that it is not taken into consideration. The aim of this review was to investigate cancer studiesin humans on the association of microbiome with composition changes in Dialister. Methods: A systematic literature search was performed using in Pubmed. In vitro and animal studies were excluded.After database search, 510 articles were found. 484 article were excluded based on the exclusion criteria. The remain ing 26 articles were identified and analysed for Dialister. Meta-Mar online software was used for metaanalysis results. Results: The meta-analysis included 26 studies with 1649 control samples and 1961 cancer samples. Compared tohealthy controls, Dialister were significantly elevated in samples from cancer patients (Hedges’g=0.907, p