Impact of Gender on the Prognosis of Patients withHepatocellular Carcinoma After Palliative Therapy

Abstract

Objectives: Sex differences are ascribed to the risk of hepatocellular carcinoma (HCC); however, whether gender dis parity also exists in the prognosis of palliative therapy is yet unclear. A retrospective cohort study was performed toassess the prognostic predictors after palliative therapy of HCC, focusing on sex differences. Methods: This retrospective cohort study consisted of 2356 patients (270 women and 2086 men) with a diagnosis ofHCC between 2006 and 2011. The patients received palliative care. Clinical and laboratory data were evaluated andcompared. Results: Overall, the two groups did not have significant sex-related differences in prognosis for overall survival (OS)of palliative care, including transarterial chemoembolization (TACE), chemotherapy, and best supportive care (BSC).Using multivariate analysis, the following were identified as independent risk factors of survival (P