Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers

Abstract

Objectives: To investigate the immune inflammatory profile in patients affected by benign salivary gland tumors (SGTs) by evaluating the blood inflammatory biomarkers. Methods: A retrospective chart review was performed between January 2015 and April 2020, collecting the data of all patients admitted for benign SGTs in our maxillofacial surgery unit. A total of 191 patients were divided into two groups: 94 with Warthin’s tumor (WT group) and 97 with pleomorphic adenoma (PA group) at histological diagnosis. The third group consisted of 90 patients randomly selected as the control group (C group). Results: The most relevant correlations were found by analyzing the values of some inflammatory biomarkers among the three groups. The neutrophil-to-lymphocyte ratio was found significantly higher in patients in the PA (p