Ventilator-Associated Pneumonia: Microbiology, Antibiotic Resistance, Changing Trends, and Clinical Implications from the 10-Year Experience of a Single Center

Abstract

Objectives: This study aimed to determine how ventilator - associated pneumonia (VAP) frequency, and antibioticsusceptibilities are affected by the changes in the intensive care unit (ICU) conditions in adult patients.Methods: In this retrospective study, 457 VAP patients diagnosed in the ICUs of a training hospital between 2008 and2017 were analyzed. Alterations in VAP rates during this period were evaluated.Results: Our results indicated that the improvement of physical conditions, and VAP prevention measures yielded aremarkable decline in the rates of VAP. VAP rates (cases per 1000 ventilator-days) decreased significantly between before2013 and 2013-2017 periods (from 16.1 to 7.1; p