Which Preoperative Inflammation Markers are More Valuable Prognostic Markers in Renal Cell Cancer Patients who Have Undergone Nephrectomy?

Abstract

Objectives: This retrospective study evaluated the prognostic significance of inflammation markers (IMs) in patientswith renal cell cancer (RCC) who had undergone nephrectomy.Methods: A total of 118 patients—39 (33.1%) were female, and 79 (66.9%) were male—were included in the study. Allmedical records were reviewed retrospectively. The cut-off values for the IMs (c-reactive protein (CRP), CRP/albuminratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammatory index(neutrophils × platelets)/lymphocytes) (SIII)) were defined by receiver operating characteristic (ROC) analysis. Overallsurvival (OS) and disease-free survival (DFS) were plotted using the Kaplan–Meier method and compared using thelog-rank test. Cox regression analysis was performed for univariate and multivariate analyses, and hazard ratios (HRs)with 95% confidence intervals (CIs) were used to quantify the indices for estimating survival.Results: An optimal CAR cut-off value of 8 was defined according to the ROC analysis. The area under the curve for CAR(0.755) for OS and DFS was greater than that for CRP, NLR, PLR, and SIII. Multivariate analysis demonstrated that CAR isan independent prognostic factor for OS (p