General Characteristics and Prognostic Factors on Survival in Neuroendocrine Tumor Patients Diagnosed with Carcinoid Syndrome: Erciyes Multidisiplinary Neuroendocrine Tumor (NET) Group Experience

Abstract

Objectives: Carcinoid syndrome is one of the functional neuroendocrin tumor symptom. It is a very rare disease and alittle known about this syndrome. We aimed a study that evaluating general characteristics and prognostic factors onsurvival in NET patients diagnosed with carcinoid syndrome.Methods: All patients diagnosed with neuroendocrine tumor were retrospectively reviewed in our institution. Thepatients diagnosed carsinoid syndrome were included in this study. General characteristics were recorded. Prognosticfactors on survival were analysed with Cox regression. Kaplan Meier method was used for overall survival.Results: Among 450 patients diagnosed neuroendocrine tumor in our hospital, 29 of them (6.4%) were presented withcarcinoid syndrome. The univariate analysis revealed that age, high tumor grade and ki67 score were correlated withpoor overall survival and the multivariate analyses revealed that older age were correlated with poor overall survival.The median OS were 61 months in all grades and 64 months for grade 1 tumors, 45 (13-76) months for grade 2 tumors,5 months for grade 3 tumors and there were statistically significant difference (p=0.007).Conclusion: Age, grade, ki67 score are important prognostic factor. Age is an independent prognostic factor that affecting survival in carcinoid syndrome patients.