Chitotriosidase and Neutrophil Gelatinase-Associated Lipocalin: New Methods as a Diagnostic Marker of Infection in Patients with Febrile Neutropenia?

Abstract

Objectives: Despite the important improvements in prevention and treatment, febrile neutropenia is still a commonchallenge in patients with certain hematological disorders. Many biomarkers have been explored to identify high-riskneutropenic patients, which need hospitalization and broad-spectrum antibiotic treatment. In the present study, firstly,we aimed to investigate serum CRP, Chitotriosidase (CtH) and Neutrophil gelatinase-associated lipocalin level (NGAL) infebrile neutropenia, non-febrile neutropenia and control groups. Secondly, to evaluate the usefulness of CRP, CtH andNGAL as a inflammatory biomarker to detect slight inflammatory change associated with infection in these patients.Methods: This was a single center prospective study that investigated ChT and NGAL as a new biomarkers to detectslight inflammatory change associated with infection in febrile neutropenia, non-febrile neutropenia and controlgroups. Therefore, 168 serum samples, which were obtained from 26 patients with hematological disorders were dividedinto three groups; Febrile neutropenia, non-febrile neutropenia and control group.Results: The mean serum CRP, CtH and NGAL levels of febrile neutropenia group were significantly higher than theother two groups (p0.05). C-reactive protein had a positive and significant correlation with CtH (r=0.548, p