Genetic Abnormalities Detected in Non-Hodgkin Lymphoma

Abstract

Objectives: To investigate the association between clinical features and fluorescence in situ hybridization (FISH) resultsof patients with non -Hodgkin lymphoma (NHL). The advances in molecular biology, cytogenetics and immunology facilitated the understanding of the pathogenesisof lymphoma. Although there are some basic prognostic indicators, the prognostic importance of genetic factors isgradually increasing. Methods: Fifty six patients who underwent genetic analysis before therapy, were evaluated retrospectively. Deparaf finized lymph node sections were used. Patients were divided into two groups according to the presence of geneticdisorder. The groups were compared in terms of clinical features, laboratory parameters and survival. Results: Genetic abnormality was present in 33 of 56 patients. The most common genetic abnormality was MYC/IGH2rearrangement. There was no difference between the survival of the groups. There was a positive correlation between Bsymptoms and the presence of genetic disorder and a negative correlation between leukocyte count and the presenceof genetic abnormality. Conclusion: Despite including small number of patients and heterogeneous histological NHL subtypes, our study mayprovide contribution to the frequency and type of genetic abnormalities in patients with NHL in Turkey.