Relationship of Serum Copper and Zinc Levels with PlasmaNT-proBNP Level in Men with Ischemic Origin Chronic HeartFailure

Abstract

Objectives: Heart failure (HF) is one of the main causes of cardiovascular mortality and mobidity today. Despite allthe advances in the diagnosis and treatment of HF, mortality and morbidity rates could not be reduced to the desiredlevels. Therefore, it is important to identify new prognostic factors in these patients. Recent studies show that micro nutrient dyshomeostasis may play a role in the pathophysiology of HF. In this study, it was aimed to investigate therelationship between copper (Cu), zinc (Zn) and Cu / Zn ratio and N-terminal pro-B type natriuretic peptide (NT-proBNP)levels in male patients followed with ischemic HF. Methods: 57 male patients who were followed up in the cardiology outpatient clinic with a diagnosis of compensatedchronic HF of ischemic origin were divided into two groups as high and low according to the NT-proBNP level, whoseprognostic limit value was reported as 1000 ng / L. The control group was composed of 24 patients with similar demo graphic characteristics, except for the presence of HF. Results: In the high nt-proBNP group, the serum Cu mean level was low compared to the nt-proBNP group (p