Does Platelet Count Affect Survival Outcomes in Patients with Malignant Pleural Mesothelioma?

Abstract

Objectives: Malign mesothelioma arises from pleura, peritoneum, pericardium and tunica vaginalis of testis. It is a primary malignant tumor that originates from mesothelial cells. It is seen relatively low but has a high mortality rate. Methods: In this study, we reviewed 41 (Malignant Pleural Mesothelioma) MPM patients who were admitted to Kocaeli University Department of Oncology between 2008 and 2014 retrospectively. Patient data were reviewed from medical records. We retrospectively analyzed the correlation between the clinical characteristics, complete blood count param- eters and survival in patients with MPM. Results: Overall survival (OS) of the entire population was 11.5 months (%95 CI; 5.86-17.19) In multivariate analysis we found a statistically significant correlation with platelet count and progression free survival (p=0.001). In our study overall survival was better in left pleura localized primary tumors, early staged tumors and patients with platelet count lower than 400.000 μl. Conclusion: Early stage disease and low platelet count have a significant prognostic importance at the time of diagnos