The Value of Preoperative Amino Terminal Pro BrainNatriuretic Peptide Levels in Showing Post-Operative KidneyFunctions in Patients Having Undergone Coronary ArteryBypass Grafting Surgery

Abstract

Objectives: Natriuretic peptides are proteins secreted by myocardium as a response to the volume and/or pressureload; especially B type Brain Natriuretic Peptide (BNP) has started to be used for the last two decades in issues such asmortality, morbidity after coronary artery surgery and estimation of major adverse cardiac issues, particularly heart fail ure. The purpose of this study is to research on the activity of BNP in predicting the risk of kidney failure after coronaryartery bypass grafting. Methods: In this study, 40 patients (33 males/7 females) whose ejection fraction was between 30% and 50% wereprospectively examined. These patients were among ones having undergone coronary artery bypass grafting by usinga cardiopulmonary machine. Blood was venously taken from patients preoperatively, on the second postoperative dayand in the sixth postoperative month in order to examine BUN (blood urea nitrogen), creatinine and plasma NT-proBNP. Results: It was observed that values of NT- proBNP examined preoperatively were negatively correlated with bothcreatinine clearances before the operation (CrCl pre-op) (p=0.031) and the values of creatinine clearance examined onthe second postoperative day (CrCl 2. day) (p=0.014).Conclusion: On the basis of our results, we are of the opinion that the preoperative BNP value might be a leadingparameter in renal monitoring in the early phase after the operation and in the treatment plan. We need prospectivestudies with high numbers of patients in this aspect.