Association between Beta-Hydroxybutyrate Levels and Survival in Sepsis Patients

Abstract

Objectives: Sepsis is a systemic inflammatory response. Beta-hydroxybutyrate is a product of ketogenesis that develops after the formation of coenzyme A from fatty acids.We aimed to evaluate the association between survival andbeta-hydroxybutyrate in sepsis patients.Methods: This is a single-center, prospective, cross-sectional study. Between May 2018 and May 2019, 51 patients diagnosed with sepsis or septic shock in Gulhane Education and Research Hospital were included in the study. Patients,grouped as non-survivors (Group I) and survivors (Group II) were included in the study and followed for 28 days aftertheir initial blood samples obtained. Plasma beta-hydroxybutyrate level analyses were measured by using Liquid Chromatography Tandem Mass Spectrometry (LC-MS-MS).Results: Within 28 days, 22 patients died (Group I); 29 patients survived (Group II). The SOFA scores were 12.45±4.22 inGroup I and 9.97±3.30 (p=0.022) in Group II, and the APACHE-2 scores were 38.05±6.23 in Group I and 34.10±7.22(p=0.046)in Group II. Beta-hydroxybutyrate levels were 20.4 µM (IQR=9.2-29.98 µM) in Group I and 54.9 µM (IQR=13.55–120.83µM) in Group II (p