Prognostic Role of Neutrophil to Lymphocyte Ratio andPlatelet to Lymphocyte Ratio in Patients with HER-2 PositiveBrain Metastatic Breast Cancer

Abstract

Objectives: Studies have been performed on the parameters that could predict the overall survival (OS) in patientswith HER-2 positive breast cancer and have a potential prognostic significance in patients with a high risk of developingbrain metastasis. This study was designed to assess the prognostic effect of blood inflammation-based markers, whichwere previously investigated in various cancers, on OS in brain metastatic HER-2 positive breast cancer. Methods: 105 patients aged over 18 years with positive HER-2 status and brain metastases and no secondary malig nancies were included in the study. Inflammation parameters at the time of brain metastasis development and beforesteroid initiation were taken into consideration. Results: Median OS of the population was determined to be 48 months (40.7-55.30, CI 95%). The median OS afterbrain metastasis (BM) was 14 months (11.76-16.23, CI 95%) in the whole group, following the development of brainmetastasis. A significant negative correlation was found between neutrophil to lymphocyte ratio (NLR) and platelet tolymphocyte ratio (PLR) and OS after BM (r=-0.413 p