BISBENZOXAZOLE DERIVATIVES HAD ANTI-PROLIFERATIVE EFFECT ON HUMAN CANCER CELLS

Abstract

A series of symmetric bis-benzoxazole derivatives were synthesized using one-pot cyclisation reaction between 4-fluorosubstituted 2-aminophenol and suitable carboxylic acids. Synthesized compounds’ anticancer activities were tested by using MTTassay on human prostate (DU145) and breast (MCF7) cancer cells. Screening results revealed that all compounds possessed a highlevel anti-cancer potential by significantly decreasing the cell proliferation in prostate and breast cancer cell lines. Our compoundsexerted their anti-proliferative effects in a dose and time dependent manner. Our results suggest that they can be highly potentsince they were biologically active even at low concentration ranges. Our study presents a series of new bis-benzoxazole basedcompounds with potential therapeutic effects against tumor cells. Therefore, characterization of new generation bis-benzoxazolederivatives will have a significant contribution on the development of new era anti-cancer drug candidates.