Dergiler / Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online) / 2020 / Cilt: 9 - Sayı: 2
ANTIBACTERIAL EFFECT OF SOME 3 -IMINO-4-SUBSTITUTED-1,2,5- THIADIAZOLIDINE 1,1-DIOXIDES
- Sayfa
- 255–264
- DOI
- —
Abstract
Organosulfur compound's functionality constitutes an essential class of therapeutic agents in current medicinal chemistry.Especially sulfonamides called sulfa drugs were performed as both chemotherapeutic agents and useful antibacterialderivatives developed for medicine. The sulfamides in the same family with the sulfonamides have similar biologicalactivities. In our research, it was studied with some 3-imino-4-substituted-1, 2, 5-thiadiazolidine 1,1-dioxides (ISTDs- 4a-d,four samples) that are five-membered cyclosulfamides. These compounds were previously synthesized and structurallycharacterized. The goals of this study are to investigate minimum inhibition concentration (MIC) values and antibacterialeffects of these ISTDs compounds on Bacillus subtilis NRRL B-209T, Escherichia coli ATCC®25922T, Micrococcus luteusNRRL B-1018T, Nocardia abscessus DSM 44432T, Nocardia cyriacigeorgica DSMZ 44484T, Pseudomonas aeruginosaNRRL B-2679T Staphylococcus aureus ATCC®6538T, Streptomyces murinus ISP 5091T.