Orşektomi Sonrası Erkek Köpeklerde C-Reaktif Protein ve Serum Amiloid A

Özet

Akut faz tepkisi doğuştan gelen bağışıklık sisteminin bir parçası olarak düşünülür. Akut faz yanıtı sırasında, akut

Abstract

The acute-phase response is considered part of the innate immune system. During acute phase response,concentrations of acute phase proteins occur. Therefore, acute-phase proteins are part of the innate immune responseand its biological function, although variable, generally relate to defense to pathological damage and restoration ofhomeostasis. Their levels fluctuate in response to inflammation and tissue injury. The main acute-phase proteins indogs are C-reactive protein (CRP) and serum amyloid A (SAA). Surgical trauma has effect on many parts of immunologicaland hematological profile. The aim of this study was to determine the perioperative dynamics of CRP and SAAin male dogs undergoing elective orchiectomy. Blood samples were collectedby jugular venipuncture in the followingorder: before the surgery (day zero), on first (day one), third (day three) and seventh (day seven) postoperative day(POD). As markers of systemic inflammation, CRP and SAA levels was determined by ELISA using commercial kits.The study showed that the CRP and SAA changes rapidly. The peak CRP and SAA concentrations were detected onthe first day after surgery. Serum CRP concentration on the seventh postoperative day was within physiological ranges,while SAA concentration was significantly higher. In conclusion, SAA and CRP measurements above basal levelsare clearly indicative of systemic inflammation in dogs.