Comparison of the Effectiveness of Rapamycin and Gabapentin Treatment in Rats with Induced Sciatic Nerve Injury

Arzu Hanım YAY, Mehmet CANPOLAT, Sefer KUMANDAŞ, Halis Ali ÇOLPAK, Dilek Günay CANPOLAT, Gözde Özge ÖNDER, Mehmet Fatih YETKİN, Gözde Ertürk ZARARSIZ

Abstract

Objective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model. Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI). Medical treatment was administered intraperitoneally for 30 days after the induction of SN injury. Results: Significant differences (p