A new spectrophotometric study with ortho hydroxy schiff base for the determination of aluminum in drug

Abstract

In this study, a Schiff base called (E)-2-((2- hydroxy -3- methoxy benzylidene)amino)-5-methylphenol (L) was used as a ligand. Spectrophotometric properties of the ligand have beendefined and the optimum conditions for determining aluminium by complex by UV-Vis.spectrophotometry. The absorbance of Al(III)-L complex obeys Beer’s law between 1.4 μgmL–1 and 13.5 μg mL–1 for the aluminium in the optimum conditions. Under optimumconditions, the determination of aluminium in Kompensan® drug was done successfully. TheLOD and LOQ values of the developed method were 0.01139 μg mL-1 and 0.0345 μg mL-1,respectively for the ligand.