Synthesis of Palladium Phthalocyanine and Investigation of Sono-Photodynamic Therapy Properties

Abstract

In this study, it is desired to apply the Sono-Photodynamic Therapy (SPDT) method to create a moreeffective therapeutic outcome. There are cell applications of SPDT in the literature, but thesonophotochemical studies are very limited. For this purpose, a new palladium phthalocyanine (PdPc) (2)was synthesized and characterized by standard spectroscopy methods. Then its photochemical andphotophysical properties were determined in DMSO. Singlet oxygen quantum yield of the complex (2)was calculated by both photochemical and sono-photochemical methods. The SPDT method (∆ =0.90)was found to be more effective than the PDT method (∆ =0.74), to obtain a high singlet oxygen quantumyield. All the results show that, SPDT improves the therapeutic effects and the synthesized PdPc can be aneffective sono/photosensitizer in PDT / or SPDT.