SUBKLİNİK HİPOTİROİDİLİ HASTALARDA TSH SEVİYESİ İLE EKOKARDİYOGRAFİK SOL VE SAĞ VENTRİKÜL SİSTOLİK VE DİYASTOLİK PARAMETRELER ARASINDAKİ İLİŞKİ

The Relationship Between the TSH Level and the LV and RV Systolic And Diastolic Parameters Evaluated By Echocardiography in Patients with Subclinical Hypothyroidism

Erkan BAYSAL, Barış YAYLAK, Bernas ALTINTAŞ, Serdar ALMACIOĞLU, Hüseyin EDE

Özet

Amaç: Subklinik Hipotiroidinin (SHT) kardiyovasküler hastalık riskini artırabilir.SHT olan hastalarda, TSH seviyesi ile sol ventrikül (SoV) ve sağ ventrikül (SaV) sistolik ve diyastolik fonksiyonlarını gösteren parametreler arasındaki ilişkiyi inceleyen bir çalışma mevcut değildir. Bu çalışmada SHT'si olan hastalarda TSH seviyesi ile ekokardiyografik olarak belirlenen SoV ve SaV sistolik ve diyastolik parametreleri arasındaki ilişkinin değerlendirilmesi amaçlandı. Metod: Çalışmaya SHT'si olan ardışık 64 hasta ile yaş ve cinsiyet olarak eşleştirilmiş 32 sağlıklı gönüllü dahil edildi. SHT'li hastalar TSH değerine göre; TSH 4,5-10 mU/l düşük TSH artışlı SHT ; TSH >10 mU/l yüksek TSH artışlı SHT'li hastalar olmak üzere iki gruba ayrıldı. TSH değeri

Abstract

Objective: Subclinical hypothyroidism (SHT) may be associated with an increased risk of cardiovascular disease. The relationship between TSH level and the left (LV) and right ventricular (RV) systolic and diastolic parameters have not been previously evaluated in patients with SHT. The aim of the present study was to evaluate the association between the TSH level and the LV and RV systolic and diastolic parameters in patients with SHT.Method: 32 healthy subjects and 64 patients diagnosed with SHT were included in the study. Patients were divided into 2 groups according to TSH level: patients with low increased TSH level SHT ( 4.5-10 mU/l) and patients with high increased TSH level SHT (>10mU/l ). The results of the patients were compared to those of the controls.Results: In the high increased TSH SHT patients, LV and RV systolic and diastolic function were significantly impaired. In the low increased TSH SHT patients, LV diastolic function was significantly impaired. TSH level were found to be well correlated with Sm (r=-0,58,p