A Unique Case of Merkel Cell Carcinoma with Ovarian Metastasis

Abstract

Background: Merkel cell carcinoma (MCC) is a rare cutaneous/mucosalmalignancy with very aggressive biology and increasing incidence.Ovarian metastasis is an exceptionally rare site for MCC, andonly two cases have been reported in the literature.Case Report: We report MCC with ovarian metastasis. A 34year-old female with previously excised MCC from preauricularskin presented with a pelvic mass 15 months after first diagnosis.Anti-cytokeratin (CK) 20 positivity, LCA (leucocytecommon antigen), and TTF-1 (Thyroid transcription factor-1)negativity confirmed metastatic ovarian MCC. There was no evidenceof recurrence or metastasis at 12 months after salpingooopherectomy.Conclusion: MCC should be considered in the differential diagnosisof primary and metastatic undifferentiated small round cell tumorsof the ovary.