Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease

Abstract

Background: Kawasaki disease is an inflammatory condition. Neutrophil to lymphocyte ratio is a marker reflecting inflammation.Aims: The aim of the study is to evaluate usefulness of neutrophil to lymphocyte ratio in diagnosis of Kawasa-ki disease and in prediction of coronary artery lesions.Study Design: Retrospective cross-sectional study.Methods: Seventy-five children with Kawasaki dis-ease and 66 controls were retrospectively enrolled. Their leukocyte, neutrophil, and lymphocyte counts wererecorded.Abnormallydistributeddatawereshown as median (interquartile range). Cases having coronary artery diameter two standard deviation above mean were diagnosed to have coronary artery lesions.Results: Median age of Kawasaki disease patients was 34 months. Twentyfive of those (33.33%) had incom-plete Kawasaki disease and twenty-six (34.66%) had coronary artery lesions. Leukocyte [12.61 (6.09)x103/?L vs. 8.48 (5.58)x103/?L], neutrophil [6.73 (4.10)x103/?L vs. 4.62 (5.47)x103/?L], and lymphocyte [4.04 (2.91)x103/?L vs. 3.02 (2.57)x103/?L] counts were significantly higher in Kawasaki disease patients com-pared to controls (all p values