Resveratrol Prevented Lipopolysaccharide-Induced Endothelial Dysfunction in Rat Thoracic Aorta Through Increased eNOS Expression

Abstract

Results: LPS administration significantly inhibited the relaxation response induced by ACh, while the relax- ation to SNP was not significantly altered. Phe- and KCl- induced contractile responses in the thoracic aorta sig- nificantly decreased in LPS-injected group. eNOS and p-eNOS expression decreased significantly in arteries obtained from LPS group rats. The impaired vasoreactiv- ity as well as decreased expressions of eNOS, p-eNOS, and SIRT1 in vessels from LPS-injected rats were im- proved by RVT treatment. Conclusion: The endothelium-dependent vasodilata- tion of the thoracic aorta was significantly inhibited by LPS administration, and RVT treatment may improve vascular endothelial function. The protective effect of RVT might be associated with increased eNOS expres- sion and activity.