A Solitary Fibrous Tumor of the Subglottic Larynx: Case Report and Literature Review

Abstract

Background: Solitary fibrous tumors (SFT) arising fromthe larynx are extremely rare; most occur in the supraglotticlarynx. Case Report: Herein, we detail a new case of a subglotticSFT presenting as a well-encapsulated soft-tissue tumor withhoarseness. It showed isoattenuation, similar to the adjacentmuscle on pre-contrast computed tomography (CT) images,and strong, heterogeneous enhancement following contrastmaterial administration, which may reflect hypervascularity.On pathological examination, it consisted of spindle cells,squeezed between abundant collagen, and focally prominentvascularity in a staghorn feature. The tumor cells were immunoreactive for CD34, BCL2 and CD99. Based on the combination of architectural and immunohistochemical criteria, we ultimately diagnosed this case as an SFT. Conclusion: Until now, only 14 cases of laryngeal SFT havebeen described in the literature: 13 located in the supraglottic areas and only one located in the subglottic/tracheal area.Therefore the present case is the second case of a subglotticSFT reported. Although rare, SFT should be included in the differential diagnosis of a well-marginated laryngeal masswith highly intense contrast enhancement, which suggestsrich tumor vascularity.