Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats

Abstract

Background: Chemerin is a recently discovered adipokine that plays a role in adipocyte metabolism. It is a novel chemoattractant adipokine whose expression and secretion are increased by adipogenesis.Aims: To evaluate the effects of probiotic supplementation on chemerin level, inflammation, and metabolic syndrome components in obese Wistar rats.Study Design: Animal experiment.Methods: We divided the experimental animals into three groups, each consisting of eight rats. Group 1 was the control group. Group 2 was the experimentally obese group, in which rats were fed with a high-fat diet. Group 3 was the obese intervention group, in which rats were supplemented with probiotics after obesity induction.Results: At the end of the study, a statistically significant difference was found between the groups in final weights, weight changes, and body mass index values (p