Prunus laurocerasus L. Meyve Ekstraktının Sıçanlarda İndometazin ile İndüklenen Gastrik Ülsere Karşı Koruyucu Etkisi

Protective Effect of Prunus laurocerasus L. Fruit Extract Against Indomethacin-Induced Gastric Ulcer in Rats

Özet

Bu çalışmada Prunus laurocerasus meyve ekstraktının, non-steroid antiinflamatuar ilaçlardan biri olan indometazinkaynaklı gastrik ülser modelinde koruyucu etkilerinin araştırılması amaçlanmıştır. Deney hayvanları dört gruba ayrıldı (Kontrol,Prunus laurocerasus, İndometazin ve Omeprazol grupları). I. ve III. gruba izotonik tuzlu su, II. gruba 500 mg/kg Prunuslaurocerasus ekstraktı ve IV. gruba 5 mg/kg omeprazol oral olarak verildi. Çalışmanın 11. gününde II, III ve IV. gruplara tek doz100 mg/kg indometazin oral olarak uygulandı. Siklooksijenaz - 2 (COX-2) ve C - reaktif protein (CRP) seviyeleri, indometazingrubunda önemli şekilde artarken (P

Abstract

In the present study, it was aimed to investigate the protective effects of Prunus laurocerasus fruit extract in the indomethacine-induced gastric ulcer model, which one of the non-steroid anti-inflammatory drugs. Experimental animals were divided into four groups (Control, Prunus laurocerasus, Indomethacine and Omeprazole groups). The groups I and III was given isotonic saline, the group II was given 500 mg/kg Prunus laurocerasus extract and the group IV was given 5 mg/kg omeprazole orally. On the 11th day of the study, a single dose of 100 mg/kg indomethacine was administered orally to the II, III and IV groups. The levels of cyclooxygenase - 2 (COX-2) and C - reactive protein (CRP) increased significantly in indomethacine group (P