Nonsteroid anti inflamatuar ilaç (NSAİİ) kullanan hastalarda oluşan gastroduodenal lezyonların önlenmesinde misoprostolun yeri

The prevention of acute nonsteroidal anti-inflammatory drug associated gastroduodenal mucosal damage by misoprostol

İlyas ÇAPOĞLU, Nihat OKÇU, Kürşad YILMAZ, Mehmet GÜNDOĞDU, İlhami KİKİ, Lale CERRAHOĞLU, M. Derya ONUK

Özet

Bu çalışmaya Ağustos 1994 - Ağustos 1995 tarihleri arasında Atatürk Üniversitesi Tıp Fakültesi Fizik TedaVi ve Dahiliye Polikliniğine başvuran ve uzun süre NSAİİ alan 53 hasta kabul edildi. 24'ü NSAİİ'a devam etti, 29 vakaya NSAİİ ile birlikte misoprostol verildi. Başlangıçta ve 4 hafta sonra endoskopik muayene yapıldı. Mide pH, kan gastrin, Na, K, BUN, Kreatinin, ALT, AST bakıldı. İki grup birbiriyle karşılaştırıldı. - NSAİİ alanlarda gastroduodenal mukoza hasarında artış vardı. NSAİİ + misoprostol alanlarda mukoza hasarında nisbi düzelme mevcuttu, istatistiki yönden fark anlamlı idi (P0.05). Epigastrik ağrı, yanma, açlık ağrısı ve gece ağrısındaki azalma NSAİİ+misoprostol grubunda anlamlıydı (P

Abstract

In this study, 53 patients who applied to Medical Faculty of Medicine Physical Treatment & Rehabilitation and Internal medicine departments between August 1994 and August 1995 were accepted. These patients had been taking NSAID for a long time. 24 patients continued NSAID only but 29 patients used misoprostol additionally. Endoscopic examination was done at the beginning and 4 weeks later. Gastric pH, blood Gastrin, Na, K, BUN, Cr, AST, ALT levels were controlled. After that, these two groups were compared with each other. In the point of NSAID users only, there was an increase in gastrodoudenal mucosal injury. But there was an improvement in (he cases of misoprostol usage with NSAID. The difference was significant statistically (P0.()5). There was a significant decrease in epigastric pain, pyrosis and pain during fasting especially in jnight pain - NSAID + misoprostol group (P