Glutathione concentration, glutathione peroxidase and superoxide dismutase activity of erythrocytes in the early onset of acute myocardial infarction

Abstract

Purpose: During the past few years, considerable interest has been focused on the possible role of oxygen free radicals in the pathogenesis of postischemic myocardial disfunction after acute myocardial infarction. Methods: The aim of this study was to evaluate the erythrocyte superoxide dismutase and glutathione peroxidase activities, and glutathione concentration of erythrocyte in 45 patients with acute myocardial infarction. Measurements from 45 healthy subjects were used as controls. The blood samples of patients were taken in the first 6 hour of the acute myocardial infarction. Results: The patients and controls were stratified according to their ages into three levels. The glutathione peroxidase (p