Cryptotanshinone mitigates ischemia reperfusion-induced testicular damage: A experimental study

Abstract

Aim: The aim of this study is to investigate the protective effects of cryptotanshinone on ischemia reperfusion-induced testisdamage.Materials and Methods: In this study, the rats were divided into 3 groups. Groups of the study are planned as follows; sham, ischemiareperfusion, and ischemia reperfusion+cryptotanshinone. Oxidant molecules such as total oxidant status (TOS), malondialdehyde(MDA), myeloperoxidase (MPO) and antioxidant molecules like total antioxidant status (TAS), superoxide dismutase (SOD) withoxidative stress index (OSI) were evaluated in the testicular tissues obtained at the end of the experiment.Results: In ischemia reperfusion group, TAS and SOD levels decreased while other oxidant parameters were increased. But inischemia reperfusion+cryptotanshinone group, the levels of anti¬oxidant parameters increased while the levels of oxidant parametersdecreased.Conclusion: These results have shown us that cryptotanshinone is highly effective against oxidative testis damage caused byischemia reperfusion.