An evaluation of neglected tumors: Giant basal cell carcinomas

Abstract

Aim: Giant basal cell carcinomas (GBCCs) which constitute approximately 1% of basal cell carcinoma are aggressive tumorscharacterized by deep tissue invasion, high risk of metastasis, and poor prognosis. We aimed to analyze demographics, treatment,and outcome of patients with GBCCs in this study.Material and Methods: Between 2017 and 2020, nine patients applied to Department of Plastic and Reconstructive Surgery andunderwent surgical treatment for GBCC were included in the study. Age, sex, localization, tumor size, treatment and comorbiddiseases of the patients were reviewed retrospectively.Results: Six patiens were male and three patients were female. The mean age was 68.6 ±3.8 years, ranging from 62 to 78 years. Thetumors were located on cheek (n=4), frontotemporal region (n=2), cheek nose lower eyelid junction (n=1), scalp(n=1) and dorsumof the hand (n=1). The largest of the lesions was 8x10 cm and the smallest was 4x6 cm.The defect sizes following tumor removalranged from 24 to 80cm2 with an average of 43,6 cm2. Nodular GBCC was the most common histological subtype (n=6), followed bysuperficial (n=2) and morpheaform (n=1). Two patients were skin grafted after excision of GBCC whereas cheek rotation flaps (n=2),cervicofacial flaps (n=3) and pedicled forehead flaps (n=2) were utilized for reconstruction.Conclusion: Since health insurance covers oncologic surgery and there is an extreme ease to reach a health professional in ourcountry, the most common reason to still encounter GBCC seems like negligence. GBCCs are rare, but they need proper interventionswhen detected. Aggressive surgery should not be avoided for better outcomes.