Predictors of mortality after transcatheter aortic valve implantation

Abstract

Aim: Transcatheter aortic valve implantation has been used widely as an alternative treatment method for patients with symptomaticaortic stenosis carrying high surgical risk. Despite technological advances and increased experience, its early and late mortality rateis still relatively high and it is important to predict upcoming cardiac events and mortality for the management of patients. In thisstudy, we aimed to investigate the clinical and laboratory parameters affecting mortality after these procedures performed in ourclinic.Material and Methods: The patients who underwent TAVI due to severe AS between May 2015 and March 2019 were investigatedretrospectively. Demographic, echocardiographic and laboratory data of all patients were recorded. During the follow-up period(mean: 556 days), patients were divided into 2 groups; deceased patients (group 1, n=13) and living patients (group 2, n=34). Thedata of the patients before TAVI procedure were compared between the two groups.Results: Among demograhic data, the ratio of chronic kidney disease was significantly higher in the deceased group. Among echoparameters, left ventricular ejection fraction was significantly lower and pulmonary artery pressure was significantly higher in thedeceased group. Of laboratory parameters, blood urea nitrogen and creatinine levels were significantly higher and toral protein levelswere significantly lower in the deceased group. Additionally, leukocyte, uric acid, CRP and CRP/albumin ratio were significantlyhigher and albumin was significantly lower in the deceased patients.Conclusion: The presence of chronic kidney disease, low left ventricular EF, high pulmonary artery pressure, high CRP levels, increasedCRP/albumin ratio and high uric acid levels preceding TAVI may be helpful to determine the risk of mortality after the TAVI procedure.