Sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia

Abstract

Aim: Hypoglycemia is associated with excessive cardiovascular mortality because of the pro-inflammatory and pro-atherothromboticpathway stimulation. Hypoglycemia is known to affect the development of sub-clinic atherosclerosis. This study aims to determinethe development of sub-clinic atherosclerosis in patients with postprandial reactive hypoglycemia by investigating thickness ofcarotid intima media and epicardial fat, and high-sensitivity C-reactive protein values and their relationships with each other.Material and Methods: 51 patients in total were included in the project, including 28 patients (37.50±10.82 years) who hadhypoglycemia symptoms and who had hypoglycemia during prolonged oral glucose tolerance test and 23 healthy adult volunteers(35.01±10.92 years) as a control group. Subjects underwent echocardiographic examination including EFT and IMT measurementusing transthoracic echocardiography.Results: Postprandial Reactive Hypoglycemia group were marked with higher high-sensitivity C-reactive protein levels (1.67±0.67vs. 1.20±0.52; p= 0.007), carotid intima media thickness (0.65±0.10 vs. 0.50±0.10; p