Comparison of preoperative myometrial invasion on MRI with intraoperative frozen section in predicting adverse prognostic factors and survival in endometrioid endometrial cancer

Abstract

Aim: There are no studies that have evaluated the accuracy of the finding of myometrial invasion in each modality in predictingadverse prognostic factors and survival. We compared the association of myometrial invasion on MRI and frozen section withpresence of adverse prognostic factors and decreased disease-specific survival (DSS) in endometrioid endometrial cance.Material and Methods: A total of 149 patients diagnosed and treated surgically for endometrioid endometrial cancer at a singleinstitution between 2010 and 2017 were included in the study. Accuracies of radiological myometrial invasion and frozen sectionmyometrial invasion in predicting the histopathological myometrial invasion, other adverse prognostic factors and DSS werecompared.Results: Frozen section had an accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV)of 89.2%, 100.0%, 84.7%, 72.8% and 100.0%, respectively in diagnosing histopathological deep (≥50%) myometrial invasion witha kappa value of 0.876 (p